my old desk had been increasingly painful to work at with every passing day, I had to slouch to fit myself into it, and slouching for longer than a few minutes makes the damaged nerve in my shoulder burn and sting so badly that its nigh impossible to think of anything else when its happening. I couldn't take it anymore, and it was a miracle to find a desk this good for so cheap
I got a Samsung Galaxy S8 and just installed Tusky, and now this is stuck in my head https://youtu.be/yzF-drvzpso
bioscience news, The New York Times source
"Electroactive bacteria were unknown to science until a couple of decades ago. But now that scientists know what to look for, they’re finding this natural electricity across much of the world, even on the ocean floor. It alters entire ecosystems, and may help control the chemistry of the Earth."
Gonna shamelessly tag @juni in on this, 'cause this seems like their sort of jam.
TL;DR the paper expands upon a 2017 paper exploring expression /growth / citrate yield differences in a producer strain given different quantities of iron. Now they’re exploring the same things in conditions of arginine or citrulline supplementation, and making comparisons between the two experiments
And by combining all this RNA seq data and sifting through it in 2 different, complementary ways (a homology-based approach, and a hidden markov model-based approach), they found their exporter
This paper is so cool, and OPEN ACCESS BABY, came out 2 months ago, researchers used a transcriptomic approach to identify a single citrate exporter that the whole phenomenon depends on, and they drew some very interesting conclusions about regulation in the process
Possible reasons "why" include:
the fungus might cope w low iron conditions by releasing tons of citrate to chelate iron from the environment, like a bacterial siderophore
it might use citrate to aid in hydrolysis of sucrose
or citrate might be an overflow metabolite
some clues to “why” may lie in the unusual growth conditions required for maximum citrate production and export: little iron (so little that it limits growth), manganese ions absent, lots of sugar substrate, low pH (<2.6)
Given the right industrial fermentation conditions, Aspergillus overproduces huge amounts of citric acid. The best producer strains can make 95 kilograms for every 100 kilograms of sugar they're fed, given optimal conditions. That is a LOT of citric acid https://link.springer.com/article/10.1007/s00253-002-1201-7
juni | shapeshifty skunk | they / she | nb lesbian | poly | microbiologist | furry artist / suit maker | Barking Points cohost |
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